Gluten Sensitivity And Stroke Risk

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tex
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Gluten Sensitivity And Stroke Risk

Post by tex »

Hi All,

A post that Kari wrote, in another thread, inspired me to write this post, and I thought that it was such an important subject, that rather than adding it to that existing thread, as another response, I decided to start a new topic.

Have we previously discussed the fact that untreated gluten-sensitivity is associated with an elevated stroke risk? I don't recall doing so, but my memory isn't what it used to be, so maybe I'm overlooking something. At any rate, here's a quote from a new study on this topic, that was released last month, in which researchers determined the stroke risk for celiac disease, based on 28,000 cases of diagnosed celiac disease, in Sweden:
Results
During follow-up, there were 785 first-stroke diagnoses in patients with CD and 2937 in reference individuals. Patients with CD were at increased risk of stroke (HR 1.10; 95% confidence interval [CI] 1.01-1.19). HRs were similar for ischemic stroke and brain hemorrhage and were not affected by adjustment for type 1 diabetes, rheumatoid arthritis, use of medication against hypertension, or dyslipidemia. The absolute risk of stroke in patients with CD was 267 per 100,000 person-years (excess risk 24/100,000). The highest risk estimates occurred in the first year, with virtually no increased risk after more than 5 years of follow-up after CD diagnosis. The HR for stroke in childhood CD was 1.10 (95% CI 0.37-3.22).
http://www.sciencedirect.com/science/ar ... 5711001157

Now, notice that only patients who had actually been diagnosed with celiac disease were considered in the study, and the stroke risk was highest at diagnosis, and declined with time, (presumably due to treatment by means of a gluten-free diet), so that after 5 years, no significant increased risk was noted. The conclusion of the researchers was that increased risk of stroke for diagnosed, (and therefore, treated), celiacs was not a major concern.

However, what this study does not discuss, is of much greater importance, IMO. It does not mention all of the undiagnosed celiacs, and others with gluten-sensitivity, who are not being treated by a GF diet. As far as I can tell, the study results definitely imply that those undiagnosed, (and untreated), individuals are definitely at an elevated stroke risk, and there is absolutely no reason to believe that their stroke risk will decline, as time passes, so long as their gluten-sensitivity remains untreated. In fact, logic would dictate that their stroke risk probably increases as time passes, as long as they remain untreated.

Note that this is not part of the researcher's conclusions, it's strictly my interpretation of what the results of the study indicate, based on the facts presented in the report. Therefore, IMO, preventing an elevated stroke risk is another incentive, (and a very powerful incentive, IMO), to follow the GF diet, for anyone who is sensitive to gluten, because clearly, according to the conclusion reached by the researchers, faithfully following the GF diet will, (over time), eliminate that increased stroke risk.

Does anyone see anything incorrect, or contrary to logic, in my interpretation?

Love,
Tex
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Post by Kari »

Hi Tex,

Thanks for digging up that research - it certainly seems to me that they (and you) are right on target. Judging from the brain fog and sluggishness I have experienced over the years, I have no doubt that heading for a stroke would have been very likely, if I didn't discover the gluten connection. Hopefully, as you (and the research) suggest, having eliminated gluten from my diet will result in a reduced stroke risk :xfingers: . I certainly feel much better than I have in a very long time.

My mother suffered several strokes, and was almost certainly gluten intolerant, since I inherited one celiac gene from her. She was always complaining of feeling bloated and uncomfortable - and the size of her stomach was proof. My sister, who has also had several strokes, says that as soon as she eats anything at all, her stomach blows up to epic proportions. I don't know the specifics about my niece, as we don't keep in close contact, but the fact that she has had a stroke at such an early age, as well as thyroid issues, certainly points to gluten sensitivity.

I wish there was something I could do to convince the two of them (along with so many others in my family) to eliminate all gluten from their lives, but without confirmation from their beloved doctors, it is a hard sell :(.

Love,
Kari
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Post by Gloria »

It makes sense to me, Tex. Hopefully, going GF has afforded me some protection against strokes. Thank you for the information.

Gloria
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Post by MBombardier »

Very interesting, and fills in a few gaps in my thinking, if you are indeed correct. My maternal grandmother had a stroke when she was 59. She was the only other lefty in our family (I am left-handed) and it paralyzed her left side. I did not know her well, as we lived states away, and only visited a few times because my grandfather never wanted my mother to marry but to take care of her parents in their old age. *smack* That's me shutting that skeleton back in the closet. My mother said that her mother often complained of not feeling very well. We concluded that she was depressed, but of course "not feeling well" could mean any number of things.

When I was visiting my father last week, he reminded me that my mother had undergone chemo for her lymphoma, which was as bad as his. My mother died of congestive heart failure in 2002, and my father blames that on the cancer/chemo, among other health factors. I hypothesize that both my mother and my father had/have at least one celiac gene, with one of them possibly having two. Only one though, since I have one celiac and one gluten-intolerance gene. It would be interesting to see what genes my brother has, but I seriously doubt he would ever test. He has enough on his plate with his own congestive heart failure. Mayo Clinic did a study (I posted it here somewhere) about the increased ejection fractions in people with CHD who went gluten-free, but my brother ignored it when I sent it to him.

I have an excellent memory--people tell me that often, and even depend on my memory, as weird at that sounds. However, I was floored by my forgetfulness a couple of times on this trip. The second one was forgetting that my mother had chemo for her lymphoma. The first one was visiting some of my in-laws where my niece reminded me that she helped us move house once and stayed with us for a week another time when her parents were out of town. I also did not remember that we used to take another niece to AWANA. I have been wondering just how far back I started suffering the gluten (and hypothyroidism) brain fog. I had five miscarriages, starting when I was 34, which is prior to these episodes I had forgotten. But I don't remember potty-training my oldest, and I was in my early 20's then.

More and more I am starting to realize that going gluten-free is probably one of the best things I have ever done for my long-term health. I know I'm not the only one who wishes loved ones would come to that understanding, too.
Marliss Bombardier

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Post by dgshelton »

Tex - When my mother had open heart surgery, the doctors could not get her platelet count to come up. She always bruised easily. I'm sure that I got my celiac gene from her because I know I got the diabetes gene from her. The DQ8 gene has been linked to type 1-type 2, also called adult onset type 1 diabetes. She was 36 when diagnosed with diabetes and I was 19. I have read that low platelet counts have been associated with celiac disease. Having a stroke, along with a horrible fungal infection, ultimately took her life. The last few meals she ate (we couldn't get her to eat much) consisted mostly of bread.

The scary thing is my 11 year old went in for his 11 year old shots and check up last week. While we were there, I noticed he had a lot of bruises on him. His platelet count was slightly low, so the doctor ordered more blood work. I told him about my recent diagnosis of celiac (I got an official diagnosis from my GI because of the celiac gene and the results I got from giving up gluten). The dr. agreed to do a celiac panel on him. I haven't heard anything from him, but we have a follow-up appointment next Friday. He had lost 2 pounds since last May. He is skin and bones with a little, noticeable, but not huge, bloated belly. His height is in the 30 percentile and his weight is in the 20 percentile for his age. His dad is 6'3" and I'm 5'. I won't be shocked if the celiac test comes back negative because mine did. I think it's time to do some Enterolab testing.

Hugs,
Denise

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Post by Kari »

Denise,

So sorry about the troubles your son is having. You are certainly right on target to have him tested, as he shows all the signs of gluten intolerance. Meanwhile, you may want to consider taking him off gluten, as it seems quite obvious that he is reacting to it. Won't surprise me if his celiac test comes back negative, so having Enterolab as a backup is great. Glad you have an open minded GI that gave you a proper diagnosis.

Lots of luck with your little boy.

Love,
Kari
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Post by sarkin »

Marliss, I've always been a great rememberer, too. It's scary that something that's so useful can slip - I really do wonder what gluten damage is reversible, and what is not.

Denise, it sounds as though your concern for your son has reached a new level - and you're definitely thinking along the right lines. A friend who has 'adult-onset Type 1' just had her kids tested - we are waiting for the results. I didn't know that about the DQ8 gene; I'll be interested to learn what those tests have to say. One of her sons is also skin and bones at the moment, and considerably shorter than his fraternal twin.

Wishing wellness for your whole family...

Love,
Sara
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tex
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Post by tex »

Denise,

I agree. I think you're right, on all counts.

Good luck with this.

Hugs,
Tex
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Post by dgshelton »

Kari - I have thought for a while that he had problems with gluten. He is such a picky eater that it's been hard to find things he will eat. He literally lived on pop-tarts, spaghetti-o's, chicken nuggets and canned green beans from the time he was three until just a few years ago when he started giving other things a try. He has a hair-trigger gag reflex and will throw up anything he doesn't want to eat. I've had him on vitamins since age three because I knew his diet was not giving him the nutrients he needed. He likes milk, so I am happy that he has been getting plenty of calcium. He's tried a few of my gluten free foods and has only liked a couple of them. Of course, I am also dairy, egg and soy free, so my stuff isn't nearly as tasty as some of the foods that are only gluten free. I'm hoping that getting the testing done will show him he really needs to give up gluten. I am also trying to appeal to his body image problems that he has recently become very interested in. He has very skinny arms and legs that have all of a sudden started bothering him. He has even asked how he can get some muscle. Maybe getting off gluten will be the answer.

Sara - I came across the information on the DQ8 gene while researching the difference in the celiac and gluten sensitivity genes. It was also interesting that Kelly's (irisheyes) daughter who was just diagnosed with Type 1 diabetes at has also has the DQ8 gene.

Hugs,
Denise

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Post by sarkin »

Denise, maybe your son is gradually becoming more ready to be more open to new foods, at his "grownup" age of 11... and it sure will come in handy, if he has to give up some familiar foods.

I bet eating the right food will help him to be stronger, since he'll be getting more nutrition that way. (That sounds so obvious, it should go without saying, come to think of it!)

I'll share your DQ8 insights with my Type 1 friend - she only tested her kids, not herself... so here's hoping if she does have that DQ8 gene herself, she didn't pass it on. (But they sure have something gluten-suspicious going on, IMHO.)

Love,
Sara
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Post by Kari »

Denise,

Your description of your son reminds me so much of my grandson (7.5 now). He has always been a very picky eater (also with the easy gag reflex), so they were very worried when they discovered that he was highly gluten intolerant. However, the transition has gone amazingly well, since the rest of the family are also eating gluten free.

My son has taken him and his older sister to karate for the past 2.5 years, and it is amazing how much it has done for their confidence. All 3 of them are working for their black belts now, and are on the demo team. I think my grand son also looks up to his dad and tries to emulate him, which has also helped with the diet transition.

Anyhow, it sounds like your son is ready for a change - perhaps you can get him into a program where he can develop muscle strength. If he starts to feel that he can excel physically, it will probably also affect his self confidence and then, hopefully, his appetite.

I know how very difficult it is to work with a child who has "food issues" - you seem to be doing all the right things to address it - he is fortunate to have such a caring mom. All the best to you and him.

Love,
Kari
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Post by Sharaine »

Tex, thank you for this information. I think your evaluation of the study's results is accurate. Also, your and others' references to brain fog here reminds me of how I felt on Monday and Wednesday of this week after being glutened on Saturday afternoon. I need to start journaling this stuff as I associated the extreme exhaustion and heaviness with the gluten, but didn't think about the fogginess.

Thank you for continuing to keep us informed on research.

Good luck to you parents and grandparents who are trying to make GF eating a reality for your family members.

Sharaine
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Post by sarkin »

Sharaine,

I started playing KenKen puzzles (like Sudoku plus arithmetic), shortly before I got sick. I could see a difference as soon as I felt better - it takes me much less time to reason them out when I'm doing well. I was a little "off" one day this week - and I could see the difference in my brain processing. I don't actually note the time it takes me, but I bet it's significantly longer on days when I've eaten something that doesn't work for me.

Now that you've learned the phrase 'brain fog' - I hope you're able to avoid it! I am realizing that a lot of 'minor complaints' I was blaming on middle age are actually symptoms - some of them rather scary, now that I think about where they might be leading.

--Sara
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Post by mbeezie »

Denise,

I have an 11 year old son as well. Two years ago I did Enterolab testing on him. He is gluten and dairy sensitive and has a DQ2 gene, so he could be celiac, not sure. If your son comes back gluten sensitive I can tell you all of my son's favorite products. He stays on the GF diet really strictly but he does cheat some with dairy. He no longer gets eczema from dairy so he justifies it. Middle school is a rough time to be on this diet.

Hopefully once he goes GF and puberty hits your son will start to fill out a bit. My son is nearly 12 and the last few months his body has really changed and he is no longer skinny. He has always been in the 25 %ile for height but we are hoping now that puberty is starting that he will catch up.

Mary Beth
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Post by dgshelton »

Mary Beth - I would love to know the things your son eats. I got a call from the pediatrician's office about my son's results, which were normal just as I expected. His ped. still wants to see him next Friday to discuss his weight loss.

Hugs,
Denise

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