Hormones and MC

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tex
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Hormones and MC

Post by tex »

Hi All,

In another thread, (about MRT testing), Mary Beth made the following comment, which reminded me of the fact that I believe that hormones are one of the largely overlooked, (by mainstream medicine, at least), but very important modulators affecting the onset and/or recurrence of MC symptoms.
My son is back to eating some of his reds without trouble but I think it is temporary. I spoke to Dr, Fine about a month ago and we talked about this. He told me that sometimes kids go into remission with food sensitivities around puberty but then they return in their 20s.
Obviously, puberty is a life stage in which hormones are, (for the first time, since birth), a dominant factor in many processes involved in development and growth. In view of the wide-ranging effects that they can have on chemical processes in so many systems of the body, it's not surprising that they might also have a profound effect on the immune system.

That's why I feel that the "experts" who claim that "kids will outgrow food sensitivities" don't know what they're talking about - that's a very short-sighted view. Sure, they may outgrow them while they're passing through puberty, but once the hormones settle down to a more normal level, those food sensitivities that have been put on hold for so many years, will once again begin to develop, and eventually cause significant symptoms, that if ignored long enough, will probably lead to more serious problems, somewhere down the road.

A similar event happens with pregnancy. Some women find that their MC symptoms virtually disappear during pregnancy, while others find that they become much worse. There doesn't seem to be any neutral ground - in virtually all cases, the intensity of symptoms are drastically shifted in one direction or the other.

The point I'm trying to make is that regardless of what happens during responses to pronounced hormonal excursions, when the hormone levels return to a more normal state, most people find that their symptomatic status returns to whatever it was prior to the hormonal changes. Note that this also applies to cases where the use of HRT triggers MC symptoms. Stopping the treatment will virtually always resolve the symptoms, (if they were originally initiated due to a hormonal response).

Is it just a coincidence that many women develop MC during perimenopause, or soon after menopause? Probably not, because the hormonal changes that occur then are quite significant, and, of course, they become permanent. Men go through a similar, (though less dramatic, and usually more gradual), change.

Maybe it's just my imagination, but I get the impression that the hormonal changes connected with puberty, seem to have a predominantly positive effect on immune system characteristics, as far as MC is concerned, (and possibly other autoimmune issues). On the other hand, the attenuation of those hormone levels, later in life, seem to have a predominately negative effect on the immune system characteristics that affect MC.

At least that's how I see it.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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mbeezie
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Post by mbeezie »

I know for sure that hormone changes can trigger mast cell activation. I told my new allergist, Dr. Legere, about how I am always more symptomatic prior to my period. He told me that Dr. Castells was the first to showw that some women produce antibodies (and at first no believed her). BTW, I felt GREAT when I was pregnant.

My sister has symptoms of mast cell activation too. She had a hysterectomy and oophorectomy and went on HRT and it was during this time that her mast cell problem became evident. SHe had chronic uritcaria for a few years and I finally convinced her to go off HRT. When she did the hives subsided. She still has mast cell issues but the HRT certainly exacerbated it.

My son got glutened the other day (Jason's Deli served him regular bread instead of Udi's and he knew immediately when he bit into it) and he has no symptoms, so I know he is not reacting any longer. I have explained this to him as best I can but I know my kiddo and he will cheat at some point. All I can do it be there for him when it when his gluten reactions start up again. Sigh.

Mary Beth
"If you believe it will work out, you'll see opportunities. If you believe it won't you will see obstacles." - Dr. Wayne Dyer
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Zizzle
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Post by Zizzle »

Norman visits me every month right before my period. I attribute it to hormonal water retention - less H20 to flush out the colon! Once my period hits, it's an instant mini-flare, which I attribute to uterine cramping nearby and the associated prostaglandins. But maybe it's hormone-related?
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