CC news - mucosal atrophy

Zizzle · Post by **Zizzle** » Tue Oct 25, 2011 12:09 pm

My Google alert just picked this up. What is the danger of mucosal atrophy, I wonder?

Mucosal atrophy in collagenous colitis: a case report

Mucosal atrophy as a potential cause of impaired colonic compliance has not yet been described as a complication in Collagenous Colitis (CC).Case presentationWe present a 51-year-old female patient with a 20-year history of diarrhea and diagnosed with CC ten years prior to her presentation. We reviewed reports from three colonoscopies performed after the diagnosis.

Overall 12 biopsies obtained in the last two colonoscopies were re-analyzed by two pathologists blinded to the aim of the study. Besides the typical histological findings of CC, the endoscopic appearance was normal, and no histological signs of atrophy were found during the first colonoscopy.Surprisingly, the second and third colonoscopy revealed a region of advanced segmental mucosal atrophy in the cecum with the mucosal height normalizing toward the transverse colon.

This pattern of atrophy was inversely related to the pattern of sub-epithelial collagen deposition, which increased toward the rectum.

Conclusion: If no chance occurrence, our observation supports the idea that additional factors, probably luminal in nature, may be co-responsible for the mucosal atrophy in this case. Thus, mucosal atrophy in the proximal colon appears to be a new candidate among the growing list of rare complications associated with long standing CC.

Author: Michael MajoresSteffen WunschBernd BlumeHans-Peter FischerChristoph Reichel
Credits/Source: BMC Gastroenterology 2011, 11:114

http://7thspace.com/headlines/397869/mu ... port_.html

Post by **tex** » Tue Oct 25, 2011 2:07 pm

Well, if mucosal atrophy exists in the proximal colon, it almost certainly exists in the terminal ileum. In the terminal ileum, mocosal atrophy would interfere with the absorption of B-12, and the re-absorption of bile fatty acids. In the proximal colon, it would reduce the uptake of electrolytes and water.

Apparently, not treating MC is probably not a good option.

Tex

MBombardier · Post by **MBombardier** » Tue Oct 25, 2011 5:34 pm

Probably the understatement of the year, Tex.

Lesley · Post by **Lesley** » Wed Oct 26, 2011 3:20 pm

That's it. I am SO miserable I am ordering the Budesonide. I am not ready to be sicker than even this. The heartburn is causing me REAL misery. Getting worse, not better. And now I am in a C phase, in horrible pain from my back and trying not to take Norco because I don't want this. I would bribe Norman with ANYTHING to visit me.
Brain fog and exhaustion - over the top!