Another Review Of Statin Effectiveness

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tex
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Another Review Of Statin Effectiveness

Post by tex »

Hi All,

A study of statin research results published in the Lancet, showed some interesting conclusions:

First, the article points out this fact:
It should be noted that: "For adults aged between 30 and 80 years old who already have occlusive vascular disease, statins confer a total and cardiovascular mortality benefit t and are not controversial."
Of course, as the article points out, 50 high-risk men aged 30-69 years need to be treated for 5 years, to prevent one event.

But then it goes on to say:
But the revised U.S. guidelines (2001) increased the target population to be treated with statins from 13 million to 36 million Americans. That increase offers huge economic implications for the manufacturers of
statins.
Their study of existing research trials concluded that:
Our analysis suggests that lipid-lowering statins should not be prescribed for true primary prevention in women of any age or for men older than 69 years. High-risk men aged 30-69 years should be advised that about 50 patients need to be treated for 5 years to prevent one event. In our experience, many men presented with this evidence do not choose to take a statin, especially when informed of the potential benefi ts of lifestyle modification on cardiovascular risk and overall health.8
Why the disagreement?
The current guidelines are based on the assumption that cardiovascular risk is a continuum and that evidence of benefit in people with occlusive vascular disease (secondary prevention) can be extrapolated to primary prevention populations. This assumption, plus the assumption that cardiovascular risk can be accurately predicted, leads to the recommendation that a substantial proportion of the healthy population should be placed on statin therapy.
http://www.ahrp.org/cms/index2.php?opti ... f=1&id=432

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by sarkin »

I believe I just said (in another topic) that I'm keeping my mouth shut with my friends and family. Apparently that was for my "should avoid gluten like the plague" loved ones. My statin-taking loved ones, that's another whole ethical and etiquette dilemma...

*Great* article, and great find. And almost 5 years old. It's actually shorter than the article I have photocopied for my next PCP visit - and from such a reputable source. (Yes, I have my itchy trigger finger on the "forward to everyone I know who takes statins" button...)

Love,
Sara
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tex
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Post by tex »

Sara,

The reason it took so long to find it, may be because that's a bootleg copy that some kind soul posted as a PDF file. If you try to access the actual original article, (IOW, in the Lancet), they want something like $31.50 for the privilege of reading it. :sigh:

http://www.thelancet.com/journals/lance ... 1/fulltext

Here's where I got the idea to search for it again, from good old Dr. Briffa, (well, good young Dr. Briffa, actually, I suppose. :lol: )

http://www.drbriffa.com/2011/12/01/aspi ... e-statins/

Happy forwarding. :lol:

Love,
Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by sarkin »

Thanks, Tex - good for the wise youngish Dr. Briffa. Glad to have access to it, and to 'share' generously :lol:

Love,
Sara
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Post by MaggieRedwings »

Great article Tex. My doc poo-poos my attitude toward statins but have quit them and she no longer pushes it on me. Success at last.

Love, Maggie
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Post by sarkin »

WTG, Maggie. Perhaps eventually your doctor will thank you for saving *her* from this unnecessarily risky class of dangerous drugs :lol:
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Post by Lesley »

Same here Maggie. I sent mine a couple of articles.
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Post by Gloria »

My PCP's office called with my blood test results today. This is the third test result I've had when I've not been taking a statin. The previous one was taken in June 2010, when I was still eating chocolate. This test reflects not eating ghee. All numbers except the triglycerides show an improvement.

Dec 2011
Cholesterol - 219
Triglycerides - 114
HDL - 67
LDL - 129

June 2010
Cholesterol - 242
Triglycerides - 106
HDL - 63
LDL - 158

The nurse didn't mention a word about taking a statin. I had told my PCP that I stopped taking it because I thought it was giving me D, though stopping it hasn't led to any lasting improvement in my BMs. Perhaps my PCP is more concerned about my osteoporosis and MC. I'd like to think he's decided that my numbers are OK.

Gloria
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Post by tex »

Gloria,

Those numbers look good to me. My total cholesterol is a little lower, (at 200), but that's only because my HDL is only half of your level. Your LDL is significantly better than mine, also. So the point is, a lower total cholesterol level doesn't do me much good, because it's mostly because of a low HDL level. :lol:

Tex
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Post by sarkin »

Gloria, I agree with Tex - your numbers don't look bad at all. The triglycerides are not high by current standards, either, though they went up. I was told mine were high years ago, when they were 144 - perhaps because they were so out of line with my then-low cholesterol.

My total, HDL, and calculated LDL are all higher; only my triglycerides are lower. According to that handy-dandy calculator I like to use (http://www.hughchou.org/calc/chol.php), the worst thing the medical standards have to say to use is that your total is 'borderline' - everything else looks great:

Your Total Cholesterol of 218 is BORDERLINE

Your LDL of 129 is NEAR OPTIMAL

Your HDL of 67 is OPTIMAL

Your Triglyceride level of 114 is NORMAL

RATIOS:

Your Total Cholesterol/HDL ratio is: 3.25 - (preferably under 5.0, ideally under 3.5) IDEAL

Your HDL/LDL ratio is: 0.519 - (preferably over 0.3, ideally over 0.4) IDEAL

Your triglycerides/HDL ratio is: 1.701 - (preferably under 4, ideally under 2) IDEAL

Glad your PCP recognized that this is not something you need to worry about!

Sara
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Post by Gloria »

Sara & Tex,

Sara - thanks for putting the numbers in the "ratio calculator." I think I'm going to be OK by not taking statins. One less thing to worry about.

Gloria
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Post by Lesley »

Mine are not great.

Total 222 is borderline
LDL 171 is high risk
HDl is 31 also high risk

CHOLESTEROL/HIGH DENSITY LIPOPROTEIN 7.2 Also high risk

No idea why I didn't get triglyceride level, but according to those #s I do have something to worry about.
But since the articles tell me not to worry, I won't. There is more than enough to worry me.
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