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The case against taking a PPI has gain some more strength with the latest research results:
The message is clear: Postmenopausal women with history of smoking who take PPIs for longer than two years have more than a 50% chance of sustaining a hip fracture, says researcher Hamed Khalili, MD. He is a gastroenterologist at Massachusetts General Hospital in Boston.
That's a incredibly bad risk, to say the least. The good news is that the increased risk appears to only affect those with a history of cigarette smoking, and it seems to fade away after 2 years have passed without taking any PPI drugs.
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Cynthia wrote:I wonder what the chances are for postmenopaual non-smokers?
Based on the deceptive trends in the conclusions of most research reports these days, I'd have to guess it's probably around 49%. I'm just joking, of course - I have no idea what it might be, but contemporary research reports tend to go out of their way to make mountains out of molehills, so that their results will appear much more impressive than they actually are.
Lesley wrote:And what does a history of smoking mean?
You would probably have to read the full report to find exactly what they mean by that term. Whatever it is, you can bet that they adjusted it to meet their goals.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I didn't read the article so I am talking from a position of relative ignorance, but I wonder if genetics were factored in? This sounds like one of those scare-stats that are touted now and then. On the other hand, since PPI's are pushed so much...?
All I can say is I am so thankful that being in remission has effectively quashed my GERD.
Marliss Bombardier
Dum spiro, spero -- While I breathe, I hope
Psoriasis - the dark ages
Hashimoto's Thyroiditis - Dec 2001
Collagenous Colitis - Sept 2010
Granuloma Annulare - June 2011
There are more than just genetics that might skew the result. Consider that smoking is no longer in vogue - that in itself is going to tilt the age bias toward older subjects, because younger people aren't as likely to smoke, nor do they break hips. That automatically puts smokers at a higher risk, because as a group, they are generally significantly older.
IOW, by selecting for smoking, they automatically selected for older subjects. Or am I wrong?
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Good question. I was pretty wild when I was younger, but I haven't smoked anything for about 25 years. I sure see a lot of young ones smoking, but that may be a local phenomenon.
Marliss Bombardier
Dum spiro, spero -- While I breathe, I hope
Psoriasis - the dark ages
Hashimoto's Thyroiditis - Dec 2001
Collagenous Colitis - Sept 2010
Granuloma Annulare - June 2011
Visit the Microscopic Colitis Foundation Website
I'm just joking, of course - I have no idea what it might be, but contemporary research reports tend to go out of their way to make mountains out of molehills, so that their results will appear much more impressive than they actually are. 
