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gastroscopy
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gastroscopy
thanks Tex for your reply, I decided to have it done and things went ok except I developed hypotention in recovery, normally I have to take meds for hypertention. The consultant said I have inflamation in my stomach and duodenum and they took biopsys, my question is I thought ceolac disease was in the small intestine am I correct? could the inflamation be something different, I just wondered what you thought, I get my results in a week so should know then, as I said before I am well now so long as I dont eat gluten and even if they say this is not ceolac disease I will sill NEVER eat it again, would appreciate your information, Beni
Hi Beni,
I can't remember how long you've been GF, but if it's less than a year, then you should still show some damage to the villi of your small intestine, if you actually have celiac disease. Of course, you may have healed enough that the damage won't qualify for a celiac diagnosis, but that's irrelevant, because if you still show any damage, then obviously it would have been worse before you started the diet, so that would confirm celiac disease, (whether your doctor is willing to admit it or not).
Sometimes the stomach is inflamed, also, in the same way that the small intestine would be inflamed by celiac disease, (with an elevated lymphocyte count). We know that the stomach can be inflamed with MC, and I suspect that it can occur with celiac disease as well, because the inflammatory pattern with celiac disease and MC are identical - they cannot be distinguished. The only difference is that for someone with a celiac gene, the damage to the villi eventually becomes much worse, but the cause of the damage is the same - T cell infiltration. In doctorspeak, they are both lymphoproliferative diseases, meaning that the inflammation is due to the infiltration of increased numbers of lymphocytes, (T cells).
I'm not sure how common it is to experience hypotensive issues following that procedure, but a low blood pressure excursion could certainly be an indication of an anaphylactic reaction. Research shows that mast cells can be stimulated to degranulate because of physical manipulation. Post-operative ileus is a rather common phenomenon following abdominal surgery, and I've experienced it myself. In post-operative ileus, the intestines stop working, (totally shut down), due to mast cell degranulation as a result of physically handling the intestines, during surgery. Mast cells can also trigger anaphylactic shock, so there's a possibility that the inflammation that was visible in your stomach and duodenum during the procedure might have been due to massive mast cell degranulation in response to the endoscope invasion. However, unless they took blood samples soon after the procedure, and tested for tryptase, they wouldn't even have been aware of this. Tryptase levels peak in about 2 hours, after a mast cell event, and then slowly decline.
It's also possible that the inflammation could be due to H. pylori, but if it turns out to be due to T cells, I wonder what's causing it. You may have another food sensitivity, or you might be reacting to a medication. It will be interesting to see what the report says.
Thanks for the update.
Tex
I can't remember how long you've been GF, but if it's less than a year, then you should still show some damage to the villi of your small intestine, if you actually have celiac disease. Of course, you may have healed enough that the damage won't qualify for a celiac diagnosis, but that's irrelevant, because if you still show any damage, then obviously it would have been worse before you started the diet, so that would confirm celiac disease, (whether your doctor is willing to admit it or not).
Sometimes the stomach is inflamed, also, in the same way that the small intestine would be inflamed by celiac disease, (with an elevated lymphocyte count). We know that the stomach can be inflamed with MC, and I suspect that it can occur with celiac disease as well, because the inflammatory pattern with celiac disease and MC are identical - they cannot be distinguished. The only difference is that for someone with a celiac gene, the damage to the villi eventually becomes much worse, but the cause of the damage is the same - T cell infiltration. In doctorspeak, they are both lymphoproliferative diseases, meaning that the inflammation is due to the infiltration of increased numbers of lymphocytes, (T cells).
I'm not sure how common it is to experience hypotensive issues following that procedure, but a low blood pressure excursion could certainly be an indication of an anaphylactic reaction. Research shows that mast cells can be stimulated to degranulate because of physical manipulation. Post-operative ileus is a rather common phenomenon following abdominal surgery, and I've experienced it myself. In post-operative ileus, the intestines stop working, (totally shut down), due to mast cell degranulation as a result of physically handling the intestines, during surgery. Mast cells can also trigger anaphylactic shock, so there's a possibility that the inflammation that was visible in your stomach and duodenum during the procedure might have been due to massive mast cell degranulation in response to the endoscope invasion. However, unless they took blood samples soon after the procedure, and tested for tryptase, they wouldn't even have been aware of this. Tryptase levels peak in about 2 hours, after a mast cell event, and then slowly decline.
It's also possible that the inflammation could be due to H. pylori, but if it turns out to be due to T cells, I wonder what's causing it. You may have another food sensitivity, or you might be reacting to a medication. It will be interesting to see what the report says.
Thanks for the update.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
allergy
thanks for the reply, I take quite a few meds so perhaps its that. I wanted to run something else by you that has been a mystery to me for years, I am hypersensitive to mosquito bites, I know lots of people say they react but I react so badly that I have to take steroids the entire time I am in a place where they are, I cover myself in deet but they still bite, less often though and if I dont take steroids I can end up in hospital for the day having iv stuff to stop the reaction, the bite swells up to an unreal area or the other thing it does is I get a huge blister, at times half the size of my thumb which if it bursts can become infected, yes I am sure you wonder why I bother going to places with mozzes but we are seasonal workers and work 6 and a half days a week from May till October and the Irish climate means we crave sun and in our winter we have to go to hot places where the mossies live! The other thing is that 35 years ago I had a tetanus shot and two days later my arm swelled up and was hard to lift, my eyes swelled up so much I only had thin slits to see out of,the docs said it was nothing to do with the shot, they gave no treatment and it took weeks to cure compleately, never had a shot for anything since. what I want to know is why am I like this is it something to do with this mast cell thing that is sometimes mentioned on this forum?could this be me? Beni
Beni,
Yes, you are correct. Your symptoms indicate that you are vulnerable to severe mast cell reactions. Whenever someone reacts that way to an injection, whether it's a mosquito bite or a vaccination, the reaction is due to massive mast cell degranulation. Your doctors were either lying like a dog, or truly ignorant, if they actually believed that your symptoms were not a result of that tetanus shot. For some unknown reason, doctors almost always try to deny that vaccinations can cause dangerous reactions. I suppose they're afraid that no one will want any injections, if they learn the truth about the risks involved. Medical treatments that result in harm to the patient, are known as iatrogenic, (which means doctor-caused, or treatment-caused). We have several other members who have had similar severe reactions to vaccinations. This type of reaction sometimes follows a flu shot.
You should always carry some Benadryl, (or whatever the medication that contains diphenhydramine is called in Ireland), in your purse, and take a dose immediately after being bitten by a mosquito, (or any other insect that causes such reactions). If the reactions include decreased blood pressure, decreased heart rate, (or a racing heartbeat), and/or difficulty breathing, because of swelling in your airways, you should ask your doctor for a prescription for an Epipen, (at least that's what they're called in this country). An Epipen is an epinephrine auto-injector, and it can save someone's life, if they are having a severe anaphylactic reaction. The epinephrine will immediately reverse the effects of the mast cell reaction, by increasing blood pressure and heart rate, and by dilating the airways to make breathing easier.
In consideration of your reaction to that tetanus vaccination, and the way that you react to mosquito bites, the episode of hypotension that you experienced following your endoscope exam is pretty convincing proof that you had an anaphylactic reaction to that procedure. You may have reacted to anesthesia, or an injection that was given, or you may have reacted to the physical intrusion of the endoscope itself, but whatever it was, you apparently had an anaphylactic reaction. Needless to say, you may need to be much more cautious about such things, in the future. If I were you, I would definitely be carrying one or more Epipens with me, at all times.
Tex
Yes, you are correct. Your symptoms indicate that you are vulnerable to severe mast cell reactions. Whenever someone reacts that way to an injection, whether it's a mosquito bite or a vaccination, the reaction is due to massive mast cell degranulation. Your doctors were either lying like a dog, or truly ignorant, if they actually believed that your symptoms were not a result of that tetanus shot. For some unknown reason, doctors almost always try to deny that vaccinations can cause dangerous reactions. I suppose they're afraid that no one will want any injections, if they learn the truth about the risks involved. Medical treatments that result in harm to the patient, are known as iatrogenic, (which means doctor-caused, or treatment-caused). We have several other members who have had similar severe reactions to vaccinations. This type of reaction sometimes follows a flu shot.
You should always carry some Benadryl, (or whatever the medication that contains diphenhydramine is called in Ireland), in your purse, and take a dose immediately after being bitten by a mosquito, (or any other insect that causes such reactions). If the reactions include decreased blood pressure, decreased heart rate, (or a racing heartbeat), and/or difficulty breathing, because of swelling in your airways, you should ask your doctor for a prescription for an Epipen, (at least that's what they're called in this country). An Epipen is an epinephrine auto-injector, and it can save someone's life, if they are having a severe anaphylactic reaction. The epinephrine will immediately reverse the effects of the mast cell reaction, by increasing blood pressure and heart rate, and by dilating the airways to make breathing easier.
In consideration of your reaction to that tetanus vaccination, and the way that you react to mosquito bites, the episode of hypotension that you experienced following your endoscope exam is pretty convincing proof that you had an anaphylactic reaction to that procedure. You may have reacted to anesthesia, or an injection that was given, or you may have reacted to the physical intrusion of the endoscope itself, but whatever it was, you apparently had an anaphylactic reaction. Needless to say, you may need to be much more cautious about such things, in the future. If I were you, I would definitely be carrying one or more Epipens with me, at all times.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
thanks
thank youfor the time and advice you have given me, much appreciated, I will now try to learn and understand more about this mast cell stuff, I cant get over how lucky we all are to have found this forum and have you and of course all the others to turn to, many thanks, Beni
Beni,
We're discovering that mast cell issues seem to be much more of a problem for many of us, than we ever realized, (and the bad part is that most doctors still don't have a clue).
You're very welcome.
Tex
We're discovering that mast cell issues seem to be much more of a problem for many of us, than we ever realized, (and the bad part is that most doctors still don't have a clue).
You're very welcome.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.