CELIAC GENE HLA-DQ2 - QUESTION

TREESE · Post by **TREESE** » Thu Sep 17, 2015 11:47 am

I got my recent Lab Blood Work Results back and noticed in the Interpretation section that the Gene, HLA-DQ2, that I tested Positive for, is one of the Variants in people with Celiac Disease.

Does that impact the CC Diagnosis in any way? Might that suggest further testing being warranted? Or further Dietary restrictions to consider? Like, separate Kitchen utensils from people who are Not gluten-free? Or, ordering items Only from exclusively gluten-free companies, to avoid cross-contamination issues?

Wow, this can Really become a Very daily learning experience, just to keep up... what ever happened to waking up to a hot cup of coffee and a nice care-free breakfast?! :coffee2:

(as "memories" by Barbra Streisand plays softly in the background)

TREESE

Post by **tex** » Thu Sep 17, 2015 12:33 pm

Treese wrote:Does that impact the CC Diagnosis in any way? Might that suggest further testing being warranted? Or further Dietary restrictions to consider? Like, separate Kitchen utensils from people who are Not gluten-free? Or, ordering items Only from exclusively gluten-free companies, to avoid cross-contamination issues?

That doesn't really change anything, because virtually all of us here are at least as sensitive to gluten as the average celiac, despite the fact that we test negative to the classic celiac blood tests. There are many genes that predispose to non-celiac gluten sensitivity, and all of us have at least 1 of those genes (unless we have 2 copies of celiac genes).

IOW, all of us have to avoid even tiny traces of gluten 100 % of the time, if we hope to prevent the development or the perpetuation of inflammation, regardless of whether we have a celiac gene, or a non-celiac gene that predisposes to gluten sensitivity.

All that the celiac gene will do for you is to allow a higher degree of damage to the villi of your small intestine, if you are exposed to gluten. Whether that is more inflammatory than the damage caused by non-celiac gluten-sensitivity genes is pretty much of an academic issue, because the clinical symptoms are the same. FWIW, I also have a DQ2 gene, and so do many others here. You can see my gene test results in the post I made today about my EnteroLab results.

Tex