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I have been experiencing some weird symptoms for the past few days. I have been on Budesonide for almost three months now and just started getting a salty taste in the left side of my mouth. It's always there but seems more obvious when I eat or brush my teeth. Coincidentally, the day I first noticed it, I have a little bit of sudden nose bleeding from that same left side. I tried to look this up online and read that it could possibly be from postnasal drip and I may be tasting it coming from my salivary glands. I don't notice any kind of drip in the back of my throat but not sure what else this might be... Side effect of Budesonide? Weight loss? Perimenopausal?
Is this possibly a histamine reaction? I have read on here that some of us with MC have histamine issues. I was also experiencing dripping from my nose a few months ago that could have been another histamine reaction. I haven't been eating any high histamine foods except for the occasional avocado, but this is nothing different than what I've been eating. I am also in the middle of a bad flare and was at that time too. Do histamine reactions only happen when we consume high histamine foods or can this randomly happen? Or does it happen more often during a flare?
Histamine issues while on Budesonide
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Histamine issues while on Budesonide
Sarah
Lymphocytic colitis since Feb 2019
Lymphocytic colitis since Feb 2019
Hi Sarah,
I'm just guessing here, because we're definitely in uncharted waters. I'm not aware of any situation where a budesonide treatment might normally cause a salty taste. And that's not a normal symptom of a histamine reaction for most of us, at least is isn't for me. So frankly, I don't have the slightest idea what might be causing it, except that, as you've already pointed out, nasal discharges can taste salty.
Histamine reactions are a result of mast cell degranulation. (When triggered, mast cells release histamine and other inflammatory agents). Histamine reactions from food only occur if the body is low on diamine oxidase enzyme (DAO), or otherwise is unable to purge excess histamine in circulation so that a histamine buildup occurs. But histamine reactions also occur as a result of any allergic reaction that provokes an IgE-based reaction, such as classic allergic reactions due to pollen, dander, pet hair, insect bites, peanut allergies, etc.
In general, budesonide (like all corticosteroids) suppresses mast cell populations and mast cell activity (degranulations). Therefore, it's very unlikely that budesonide would cause a histamine reaction, unless you were allergic to it. That said, if you were allergic to it, it's possible that it might cause a salty taste because it triggers a nasal drip.
But that's just my opinion. Maybe someone else has better information.
Tex
I'm just guessing here, because we're definitely in uncharted waters. I'm not aware of any situation where a budesonide treatment might normally cause a salty taste. And that's not a normal symptom of a histamine reaction for most of us, at least is isn't for me. So frankly, I don't have the slightest idea what might be causing it, except that, as you've already pointed out, nasal discharges can taste salty.
Histamine reactions are a result of mast cell degranulation. (When triggered, mast cells release histamine and other inflammatory agents). Histamine reactions from food only occur if the body is low on diamine oxidase enzyme (DAO), or otherwise is unable to purge excess histamine in circulation so that a histamine buildup occurs. But histamine reactions also occur as a result of any allergic reaction that provokes an IgE-based reaction, such as classic allergic reactions due to pollen, dander, pet hair, insect bites, peanut allergies, etc.
In general, budesonide (like all corticosteroids) suppresses mast cell populations and mast cell activity (degranulations). Therefore, it's very unlikely that budesonide would cause a histamine reaction, unless you were allergic to it. That said, if you were allergic to it, it's possible that it might cause a salty taste because it triggers a nasal drip.
But that's just my opinion. Maybe someone else has better information.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.