EnterolLab Results in

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ant
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EnterolLab Results in

Post by ant »

Dear MCers,

My EnteroLab results have arrived and I thought I would post the full email since their interpretations, recommendations and caveats might be interesting.

I am clearly sensitive to Gluten and Diary (and probably Soy - a "9", when "10 and above" is a problem)

I am not quiet sure what the differences is between "Fecal Anti-gliadin IgA" and "Fecal Anti-tissue Transglutaminase IgA".

I also seem to have a double wammy on the genes....HLA-DQB1*0201 and HLA-DQB1*0302. Hmmmm.....Does this suggest that my road to recovery is going to be longer and harder? Will I ever be able to eat cheese and ice cream again? (Gluten, I am sure is never.)

On the bright side :grin: at least I now know the underlying cause of my MC. Also, not to tempt the Fates :knitting: :knitting: :knitting:, I have just had 6 days without D and 50% Normans :grin:

I am still on full Entocort, so coming off the meds is an ordeal I still have to go through. But with this wonderful board and all the kind people on it, I will keep a positive attitude.

All the best, Ant

----------------------------------------------------------------------

Date: 8/14/2009
Enterolab Test Results

A) Gluten Sensitivity Stool and Gene Panel

Fecal Anti-gliadin IgA: 92 Units
Fecal Anti-tissue Transglutaminase IgA: 70 Units
Quantitative Microscopic Fecal Fat Score: Less than 300 Units
Fecal Anti-casein (cow's milk) IgA: 15 Units
HLA-DQB1 Molecular analysis, Allele 1: 0201
HLA-DQB1 Molecular analysis, Allele 2: 0302
Serologic equivalent: HLA-DQ 2,3 (Subtype 2,8)

C) Egg, Yeast, and Soy Food Sensitivity Stool Panel
Fecal Anti-ovalbumin (chicken egg) IgA: 8 Units
Fecal Anti-saccharomyces cerevisiae (dietary yeast) IgA: 6 Units
Fecal Anti-soy IgA: 9 Units

Interpretation of Fecal Anti-gliadin IgA (Normal Range is less than 10 Units):
Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.

Interpretation of Fecal Anti-tissue Transglutaminase IgA (Normal Range is less than 10 Units): You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.

Interpretation of Quantitative Microscopic Fecal Fat Score (Normal Range is less than 300 Units): Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no malabsorbed dietary fat in stool indicating that digestion and absorption of nutrients is currently normal.

Interpretation of Fecal Anti-casein (cow's milk) IgA (Normal Range is less than 10 Units): Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have two copies of the main genes that predispose to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Having two copies of a gluten sensitive or celiac gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

Interpretation of Fecal Anti-ovalbumin (chicken egg) IgA (Normal Range is less than 10 Units): Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation of Fecal Anti-saccharomyces cerevisiae (dietary yeast) IgA (Normal Range is less than 10 Units): Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation of Fecal Anti-soy IgA (Normal Range is less than 10 Units): Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

For more information about result interpretation, please see http://www.enterolab.com/StaticPages/Fa ... tation.htm
Stool Analysis performed by: Frederick Ogunji, Ph.D., EnteroLab
Molecular Gene Analysis performed by: American Red Cross
Interpretation of all results by: Kenneth D. Fine, M.D., EnteroLab
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mbeezie
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Post by mbeezie »

Hi Ant . . . fellow double DQ-1er

Well, your results might answer some questions about your continued symptoms. I would think that getting off dairy is the next step. FYI, my soy result was 9 and I am highly sensitive to soy, so even though your value is still "normal", it may mean you need to do a trial of soy free. I hope and pray that you don't have as many sensitivities as many of the double DQ1s do, but time will tell.

I feel your pain with the thought of giving up dairy. I always said Dairy Fat was my favorite food group. But the truth is, I haven't missed it as much as I thought I would. I have found acceptable substitutes. Not sure what you will be able to find comercially there, but here we have some coconut milk ice creams available. I actually have made delicious homeade coconut milk ice cream for my son - can't tell the difference. And sorbet is always an option. As for cheese, the only good casein free cheese I have found is a soy based cheese (for pizza or casseroles) is Follow Your Heart - it actually melts.

Yeah for your positive attitude :grin:

Take care,

Mary Beth
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Post by ant »

Dear Mary Beth (and fellow double DQ-1er)

Thanks so much for your quick reply. I wonder how many there are with the double gene? Of course, most people will not have been tested. I am sure you a right about my sensitivity to Soy and I also suspect egg.

I have been DF and SF for the last three weeks, as well as GF and avoiding raw salad. I have been off eggs and Dream Rice for 5 days. I have also been keeping off shellfish. Not sure why off shellfish - just thought it was risky. But maybe I can try shellfish.... it would add variety to the menu.

To be honest I probably still get quite a bit if cross contamination (cc) as I eat out a lot. I try and stick to steak, rice, roast potatoes, steamed vegetables, nuts (but not peanuts), risotto without cream or cheese, GF pasta and tomato sources (I try and make sure there is no G or soy in the tomato sources), and rice porridge with honey. When I make the source myself I use garlic, onion and peeled tomatoes. I use "Mary's Gone Crackers" GF biscuits for snacks with wine - which I still drink (cut out all other alcoholic drinks). I hope I can keep drinking wine - not only is it a pleasure, it makes me look less "odd" when I am socializing with people. All best Ant
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Post by mbeezie »

Ant,

I have discovered that my sensitivity to soy is the lecithin component, which is why I think my EL test was negative but I still have a problem. Lecithin is also found in egg, corn and peanut. I suggest eating raw nuts if you have a problem with peanuts - often when nuts are roasted they use peanut oil. Soy lecithin is in EVERYTHING! It is a dose response sensitivity, meaning you may tolerate a small amount occasionally.

Mary Beth
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Post by ant »

Dear Mary Beth

Thanks for your follow up response regarding Lecithin. So that makes corn, including corn on the cob, a no no. I do not think I have been eating much but I will watch out.

Roasted nuts are the norm in restaurants so thanks for the warning. In fact I have been eating some while making my last post...... I will keep my :xfingers:. If it is dose dependent maybe the Entocort will keep it from doing too much damage.

Best, ant
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Post by kscolorado »

Hi Ant, looks like we share the same genes! I am still waiting for my soy results but suspect that I do have a problem with it as well. Looks like you have more answers to help you on your way to healing!
Kathy
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Post by tex »

Hi Ant,

I think you have jumped to the wrong conclusion - you are not a "double DQ" anything. Your genes are HLA-DQ 2,3 (Subtype 2,8), and they are exactly the same as Kathy's genes, (as she pointed out). Also, Matthew, Mike, (mle_ii), Pat, Trace, and Wendy, (piemom). These are both celiac genes, and they are the two most common celiac genes, (in fact, they are the only two celiac genes recognized by mainstream medicine, though that is incorrect, of course - the DQ1 genes are also clearly celiac genes, since they trigger a small portion of total celiac cases). IOW, you received a DQ2 gene from one of your parents, and a DQ8 gene from the other - meaning that each of them carried at least one celiac gene.

Now, if you had two copies of the DQ2 gene, for example, rather than one of each of the two main celiac genes, then you would have double DQ2 genes, which would qualify you as a member of the "double DQ club". Andrew, (thedell19), and Bob H, (bobh) both have double DQ2 genes, for example.

Here's another way to look at your gene results:

HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0302
Serologic equivalent: HLA-DQ 2,3 (Subtype 2,8).

IOW, your recovery shouldn't be significantly more difficult than a "normal" case of MC, (if there is such a thing as a normal case. LOL). Unless something alters your genes, again, you probably will always remain intolerant of all dairy products.

Your Fecal Anti-gliadin IgA result of 92 units, means that your body is producing antibodies to the alpha gliadin peptide, (found in gluten), upon which the test is based. IOW, you're intolerant of gluten.

Your Fecal Anti-tissue Transglutaminase IgA result of 70 units, means that your immune system is attacking your own tissue, (which is an autoimmune reaction, of course).

Your egg white, yeast, and soy results are very similar to mine. I had 5, 6 and 8 units, respectively.

Do you mind if I post your results in our accumulated lists here:

http://www.perskyfarms.com/phpBB2/viewtopic.php?t=10084

and here?

http://www.perskyfarms.com/phpBB2/viewtopic.php?t=10089

Thanks,
Tex
:cowboy:

It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
ant
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Post by ant »

Hi Kathy

Same genes... :shakehands: Glade to see from another post that you will be staying here as a "CDer". Hope your Soy tests come out ok. Wishing you all the best, Ant

Hi Tex

Happy for you to post my results on the accumulated lists and thanks for putting me straight on how to look at my genes. Also thank you for the clear explanation about Fecal Anti-gliadin IgA and Fecal Anti-tissue Transglutaminase IgA. I am still on the steep learning curve.........

Wishing you all the best, Ant
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