Reviewing the following article again, concerning collagenous sprue, which was published on February 4th, of this year, this phrase catches my eye:
Their report also indicates that out of 22 patients tested, only 17 had HLA alleles DQ2 or DQ8, indicating a genetic predisposition to celiac disease.
I can only conclude that the authors are just plain mistaken, when they make the following statement:
Now, except for certain hard-headed GI docs, who are slow learners, most of the rest of us have known for some time, that those two genes are not the only ones that predispose to celiac disease, so claiming that those collagenous sprue patients who did not have either a DQ2, or a DQ8 gene, could not have "celiac disease", is just plain dumb. In fact it's"Celiac disease can be excluded in the absence of HLA-DQ2/DQ8," the authors point out, adding that in these patients, the etiology of collagenous sprue "remains enigmatic."
And these guys work for the Mayo Clinic. The report shows that of the 30 patients with collagenous sprue, whose cases were studied:
Well duh! What does that sound like? It sounds like gluten sensitive enteropathy to me, otherwise known as celiac disease. If it walks like a duck, quacks like a duck, etc., . . . The convoluted thinking of some GI docs, never ceases to amaze me.All had villous atrophy; two-thirds had total villous atrophy.
http://www.medscape.com/viewarticle/716491
Probably, some day they will realize that collagenous sprue is part of the spectrum of diseases known as microscopic colitis, but that shouldn't disqualify it from a classification as celiac disease, since microscopic colitis is also a form of celiac disease, (a designation which will require even more time, to be officially accepted).
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