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It is well known that PPIs and H2-receptor blockers cause MC for many patients, but I've always wondered about the details of how they cause the disease. Apparently the drugs cause MC by inducing food intolerances, (due to the fact that interfering with acid production in the stomach causes incomplete digestion). This is basically what we always suspected, so it is good to see that research validates our suspicions. Note that it only takes about 3 months of taking the drugs, for food intolerances to beginning showing up. Here's an abstract of a research article that explains how it happens:
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I'd better clarify that a bit. Note that the research only determines that the PPIs and H2-receptor blockers cause food intolerances to develop. The inference that this effect can result in the development of MC, is strictly an extrapolation that I made, (since it is common knowledge that food intolerances are one of the primary causes of MC. IOW, the researchers didn't mention any specific diseases that might develop as a result of the food intolerances, they only verified that the drugs tend to cause food intolerances.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex I understand that very well, I just read the abstract of the article, what I just wrote were (like yours) my conclusions. I thought if medication can cause food allergies (this was about IgE), why also not food intolerances? It is known in medicine that some kind of medication can be the trigger of MC. Also there are, at least, some indications that gluten can cause MC. IMHO (I like using these abbreviations makes me feel a bit like one of you, native writers ) ) this may explain why some get MC after the use of certain medication and some get it out of the blue.
I would sure like to get off of mine. I've taken something for my stomach since 1982, nonstop. Before that I used Creamalin, and Maalox as needed for years before. Now if I go without, even one day, in the middle of the afternoon of the first day I start getting that burn. And it becomes increasingly intense as the day goes on, and usually I get sick in the middle of the night. As soon as I take a pill, within about six hours, it goes away. I wish I could NOT take them, but it's a scary thing for me because I get so sick. I've tried the wives tales things, vinegar, etc. They make it worse!
Visit the Microscopic Colitis Foundation Website
Here's an abstract of a research article that explains how it happens:
