Mean Corpuscular Hemoglobin Concentration, (MCHC)

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tex
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Mean Corpuscular Hemoglobin Concentration, (MCHC)

Post by tex »

Hi All,

My doc's nurse just faxed me a copy of the results from a CBC that we did yesterday. Everything looks surprisingly good, except for two minor items. My red count, and the related tests are back to normal, and surprisingly, my cholesterol is down, (I have no idea why. :lol:). I was concerned about my eosinophils, and my basophils, because they've been up a little, in the past, but they're now normal, so that's good.

The only suspicious items are my lymphocyte count, and my Mean Corpuscular Hemoglobin Concentration, (MCHC), which is a calculation of the average concentration of hemoglobin inside a red cell. I'm not too excited about the low lymphocyte count, because for at least the last 10 years, my lymphocyte percentage has almost always been low, and my actual lymphocyte count has always been in the low part of the normal range. This time, though, the actual lymphocyte count is low, at 1.04, (normal range is 1.2 - 3.4 K/uL). :shrug:

Decreased MCHC values, (known as hypochromia), are seen in conditions where the hemoglobin is abnormally diluted inside the red cells, such as in iron deficiency anemia, and in a condition known as thalassemia, (which is an inherited condition in which the body makes an abnormal form of hemoglobin). Assuming that thalassemia is not the problem, I'm wondering about my B-12 level. A while back Polly pointed out to me that I may need to either get a monthly shot of B-12 or take a sublingual supplement, since B-12 is absorbed in the terminal ileum, and a significant portion of my terminal ileum was removed, along with my colon, (I'm guessing it may have gotten damaged during the surgery, but maybe it was just worn out, like my colon. :lol:)

I faithfully bought a new bottle of sublingual B-12, and I remember taking one of them, but I don't recall taking any since then. :roll: I reckon I'll start taking them regularly, just in case.

In fact, when I was discharged from the hospital, my MCHC was in the normal range, (very near the bottom of the range). Each test since then, however, has shown a slightly reduced number, so the trend is steadily downward, and the result of this test was 31.5, (normal range is 33.0 to 37.0 gm/dL). That's still only slightly down, but I don't like the looks of the trend. My MCH level is low normal, though, so I couldn't be severely low on B-12, or that number would be elevated, (unless I had pernicious anemia, of course, but I shouldn't have that).

Or, can anyone suggest any other reason why my MCHC would be down?

Tex
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Post by mbeezie »

Tex,

Have you had a check of your serum ferritin? That would be a better indicator of an iron deficiency anemia. Are you still taking the megadoses of B vitamins? I'm assuming your folate is normal. The low MCHC and lower than normal cholesterol could be related if it is a pernicious anemia or absorption problem. I'm leaning towards a problem with B12 absorption and I wouldn't rule out the possibility of pernicious anemia.

Mary Beth
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Post by tex »

Hi Mary Beth,

I looked back at my test results done over the years, and I can't see where my ferritin level has ever been checked. The last time, (only time), that my B-12 and folate levels were checked, was at the end of July, last year, 9 days after a TIA event, (triggered by MSG, IMO). At the time, my B-12 checked at mid-range, and my folate was near the high end of the normal range. This was before I started taking the Metanyx, (B-12, B-9, and B-6 supplement), and yes, I have continued to take it.

I apologize - I apparently misled you on the cholesterol level. I didn't mean to suggest that it was below normal, because it definitely is not. It's just 7.5% lower than it was a year ago, and lower than it has been in at least several years. The last result was 211, compared with 228, a year ago.

I've also started taking a 2,500 mcg sublingual B-12 lozenge daily, after seeing those test results. Do you consider the sublingual lozenges to be effective, or do you feel that I would be better off with a monthly injection, instead, as Polly originally suggested? I have an appointment with my GP, 10 days from now, to check my progress with the BP med, (and to discuss the recent CBC results). I hope I can remember to bring this up, when I'm there.

Thinking along the same lines as you suggest, it's known that megadoses of folate, (above the upper limit of 1 mg per day for men), can mask the symptoms of B-12 deficiency. Hmmmmmm. Metanx contains 3 mg of L-methylfolate Calcium, which, according to the manufacturer's website, is the equivalent of taking 19 folic acid tablets daily, (1 mg each). That's a lot of folic acid. :shock: Since my folate level was high before I started taking Metanyx, there's no telling what it might be now. It's water soluble, though, so theoretically, at least, the kidneys should prevent it from getting very far out of hand, I would think. Also, since it's water soluble, (rather than fat soluble), I would guess that a high percentage of folate absorption might occur in the colon, rather than the small intestine, but I'm just guessing, here. If that is true, then a lot of the folate that I'm ingesting, should be passing right on through, with an ileostomy in place. :shrug: At that dosage rate, though, maybe I should have those two items tested, just to be on the safe side.

Thanks,
Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by mbeezie »

Tex,

Yes, have them run a few more tests to figure out what's going on. Your level was not that low and you are not really symptomatic yet, so I would probably see if sublingual would do the trick first. Shots are painful, inconvenient and more expensive, but sometimes they are needed. You will have a better idea of which direction to go once you get test results back.

Cholesterol levels generally reflect diet from 6-8 weeks ago - can't remember when your surgery was but seems like it was about 8-10 weeks ago, so maybe that's what the change means. Lower cholesterol levels are sometimes seen with pernicious anemia.

Keep us posted.

Mary Beth

PS: Was in your neck of the woods this weekend. Despite the rainy weather it was a real treat to see the beautiful wildflowers on our drive to central Texas. Hoping all this rain will wash away some of the pollen . . . yikes, allergies have been terrible this spring.
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Post by tex »

Mary Beth,

You're in the ballpark at 10 weeks. My surgery was February 3rd.

Speaking of allergies, I've noticed that my allergies have been so mild this spring, that I haven't needed to take any antihistamines, for the first time in years, and yet tree pollen levels are being reported as the highest in at least 5 years, I believe. I think that's connected with my high blood folate levels. Since this is a separate topic, and it might be significant, I'm going to start a new topic on it. I think you'll find it very interesting.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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