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A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value
Fecal Anti-gliadin IgA 10 Units (Normal Range is less than 10 Units)
Fecal Anti-tissue Transglutaminase IgA 6 Units (Normal Range is less than 10 Units)
Quantitative Microscopic Fecal Fat Score Less than 300 Units (Normal Range is less than 300 Units)
Fecal Anti-casein (cow’s milk) IgA 9 Units (Normal Range is less than 10 Units)
HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6)
My Enterolab Test Results - Paging Tex and others to read
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Wow, I'm stumped. You were eating gluten when you submitted the samples? The anti-gliadin is a very sensitive test, and not very specific. Given these results, I'd say you're NOT gluten or diary intolerant! But I'm no expert...
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
Now Enterolab says I AM gluten sensitive. See their following interpretation...
"Interpretation of Fecal Anti-gliadin IgA: Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well."
"Interpretation of Fecal Anti-gliadin IgA: Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well."
Hmmmmmm. Those results are kind of surprising, aren't they. Of course, the gliadin result is technically a positive result, but like you, I'm surprised at the low readings. The negative TTG result is especially surprising, since it implies that you were not experiencing an autoimmune reaction at the time the sample was taken. 
I would suggest that you ask your doctor to test you for IgA deficiency. We have at least a couple of other members who are IgA deficient.
In the meantime, do you mind if I add those results to our "collection" here:
http://www.perskyfarms.com/phpBB2/viewtopic.php?t=10089
and here:
http://www.perskyfarms.com/phpBB2/viewtopic.php?t=10084
?
Tex
I would suggest that you ask your doctor to test you for IgA deficiency. We have at least a couple of other members who are IgA deficient.
In the meantime, do you mind if I add those results to our "collection" here:
http://www.perskyfarms.com/phpBB2/viewtopic.php?t=10089
and here:
http://www.perskyfarms.com/phpBB2/viewtopic.php?t=10084
?
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Rich,
It doesn't matter that you were not eating gluten for the test, because Enterolab's anti-gliadin test is so senstive that it can accurately and reliably detect gluten sensitivity at least a year after gluten has been removed from the diet. Casein antibody production will quickly fade away, after all dairy products are removed from the diet, so that after a couple of weeks, they might not be reliably detected in a stool test.
Tex
It doesn't matter that you were not eating gluten for the test, because Enterolab's anti-gliadin test is so senstive that it can accurately and reliably detect gluten sensitivity at least a year after gluten has been removed from the diet. Casein antibody production will quickly fade away, after all dairy products are removed from the diet, so that after a couple of weeks, they might not be reliably detected in a stool test.
Someone misinformed you about those tests. What you say is true for the blood tests, but the Enterolab anti-gliadin stool test is in an entirely different league. It is several orders of magnitude more sensitive than the blood tests, and it is extremely specific. It's sensitive enough to detect gliadin antibodies in the stool, at least a full year after gluten has been removed from the diet, (with virtually 100% reliably), and in some cases, it can still detect gliadin antibodies up to 2 years after gluten has been removed from the diet. It's so specific that it will only detect antibodies to the alpha gliadin protein fraction in wheat. IOW, it will not detect antibodies to the beta, gamma, or delta fractions of wheat gliadin, nor will it detect antibodies to any of the glutenin fractions in wheat gluten, to which celiacs react. Furthermore, it will not detect antibodies to any of the prolamin protein fractions of hordein, (barley), secalin, (rye), nor avenin, (oats). A test can't possibly be more specific than that.Zizzle wrote: The anti-gliadin is a very sensitive test, and not very specific. Given these results, I'd say you're NOT gluten or diary intolerant! But I'm no expert...
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Rich,
Yes, your family doc can test you for IgA deficiency. And yes, according to that test result, you are indeed gluten-sensitive.
If you turn out to be IgA deficient, that would explain why your test results were so low, and it would bring the TTG and casein test results into question. IgA antibody tests don't work reliably for someone who is not capable of producing normal levels of IgA. IOW, that deficiency makes one prone to false negative results.
Thanks, I'll add your results to the lists.
Tex
Yes, your family doc can test you for IgA deficiency. And yes, according to that test result, you are indeed gluten-sensitive.
If you turn out to be IgA deficient, that would explain why your test results were so low, and it would bring the TTG and casein test results into question. IgA antibody tests don't work reliably for someone who is not capable of producing normal levels of IgA. IOW, that deficiency makes one prone to false negative results.
Thanks, I'll add your results to the lists.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Rich,
FWIW, that 0602 allele predisposes you to neurological disorders caused by gluten sensitivity. That doesn't mean that they will develop, it just means that you have the genes that make you a candidate. You have the same genes as Dee and Joan.
Tex
FWIW, that 0602 allele predisposes you to neurological disorders caused by gluten sensitivity. That doesn't mean that they will develop, it just means that you have the genes that make you a candidate. You have the same genes as Dee and Joan.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hi Rich,
I agree with the advice you've already been given. You are definitely gluten-sensitive with a value of 10. I have heard Dr. Fine say that the "degree" of gluten sensitivity is not an issue. IOW, it's like being pregnant.......you can't be just a little bit pregnant. It's all or nothing! A 10 means that you are gluten-sensitive, period.
Love,
Polly
I agree with the advice you've already been given. You are definitely gluten-sensitive with a value of 10. I have heard Dr. Fine say that the "degree" of gluten sensitivity is not an issue. IOW, it's like being pregnant.......you can't be just a little bit pregnant. It's all or nothing! A 10 means that you are gluten-sensitive, period.
Love,
Polly
Blessed are they who can laugh at themselves, for they shall never cease to be amused.
Thanks Joan,
Sorry about that slip. It's narcolepsy that is associated with the DQB1*0602 gene.
I tend to believe that avoiding gluten will prevent the development of additional autoimmune diseases, and these conditions should also be related.
Tex
Sorry about that slip. It's narcolepsy that is associated with the DQB1*0602 gene.
I tend to believe that avoiding gluten will prevent the development of additional autoimmune diseases, and these conditions should also be related.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Polly,
Actually, there's a bit more to it, and there are other genes involved - the 0602 gene is strongly associated with narcolepsy-cataplexy, but apparently 24% of the general population carries the gene, according to this article. You might want to read this, if you're curious about it, but the prevalence is so low in most ethnic groups, that it's probably nothing to lose any sleep over.
In the study cited, of the groups studied, Californians carry the highest risk, with France and the UK coming in second and third. 
The UK link could possibly imply a gluten connection.
Since you're heterozygous for the gene, your risk is probably pretty low. Cataplexy, as you probably know, is a sudden muscular weakness brought on by strong emotions (though many people experience cataplexy without having an emotional trigger), so if you don't have this issue, you're probably home free.
http://emedicine.medscape.com/article/1188433-overview
Love,
Tex
Actually, there's a bit more to it, and there are other genes involved - the 0602 gene is strongly associated with narcolepsy-cataplexy, but apparently 24% of the general population carries the gene, according to this article. You might want to read this, if you're curious about it, but the prevalence is so low in most ethnic groups, that it's probably nothing to lose any sleep over.
In the study cited, of the groups studied, Californians carry the highest risk, with France and the UK coming in second and third. The UK link could possibly imply a gluten connection.Since you're heterozygous for the gene, your risk is probably pretty low. Cataplexy, as you probably know, is a sudden muscular weakness brought on by strong emotions (though many people experience cataplexy without having an emotional trigger), so if you don't have this issue, you're probably home free.
http://emedicine.medscape.com/article/1188433-overview
Love,
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.