A question about the gluten sensitivity genes

[IDreamInColor]

Ok, so my testing showed that I have double DQ1 genes, the report states that both of my parents had to have at least one of these genes in order for me to end up with both. My question ....does that mean that my siblings also have double genes like I do?

[tex]

No. They each get one gene from their mother, and one from their father.

Tex

[IDreamInColor]

Thank you Tex, so does that mean that passing genes onto your children is random?...If all four of us siblings have the same parents some of us may get a gene, and some of us may not, some of us get double genes and some of maybe only one, or none?

[tex]

That's correct. Each offspring will have one gene from each respective pair in the DNA chain of both parents. For example, if one parent has WX genes, and the other has YZ genes, then ideally, (according to the laws of probability), four offspring would have the gene combinations WY, WZ, XY, and XZ. (Of course, any one of them could have any of these combinations, and there is even a slim chance that they could all have the same combination.)

If both parents happen to have a single copy of the same gene, such as XY, and XZ, then the possible combinations/permutations would be XX, XZ, YX, and YZ. IOW, ideally, 3 out of 4 will have the "X" gene.

If one parent is homozygous, (has 2 copies of the same gene), such as XX, and the other is heterozygous for the same gene, such as XY, then the possible/probable permutations are XX, XY, XX, XY. IOW, in that case, (ideally), half the offspring will be homozygous, (and the other half will be heterozygous), but every one will have at least one "X" gene.

Tex