Are You Taking A Phytosterol Supplement?

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tex
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Are You Taking A Phytosterol Supplement?

Post by tex »

Hi All,

Phytosterols are supposed to provide a healthy "natural" way to reduce cholesterol levels. Unfortunately, research has turned up a very negative aspect of this type of supplement - direct damage to the heart muscle, (at least this is what happens to rats whose diet contains these supplements). :shock:

Issues such as this are exactly the reason why I am opposed to the use of "functional foods", (otherwise benign foods, or even junk foods, which are "spiked" to provide some special health enhancement). IMO, in general, it's probably always best to steer clear of foods which are designed to provide micromanagement of nutrients. We should get our nutrients from whole foods, not from nutrient supplements, or from junk foods that are claimed to have special health benefits, because of some "magic" ingredients that have been added. Whole foods often contain offsetting ingredients which counteract the ill effects of such ingredients which, when isolated, and ingested by themselves, may be hazardous to our health.

From a recent blog by Dr. Briffa:
I was interested to read about a recent study in which the effect of sterols on rat heart cells was assessed [1]. The cells were exposed to levels of sterols commonly found in the bodies of individuals ingesting sterols. The cells ended up incorporating the sterols at the expense of cholesterol. However, at the same time, the metabolic activity of the heart cells decreased, as did their capacity for growth. In short, exposing heart cells to sterols appears to, err, poison them.

The authors point out, that the results of this study cannot necessarily be translated into conclusions about the effect of these compounds on heart health, but add that the findings “raise[s] concerns about the safety of long-term exposure to physiologically relevant PS [phytosterol] concentrations.”
The red emphasis is mine, of course.

http://www.drbriffa.com/2011/04/25/heal ... art-cells/

Here's an abstract of the original research article:

http://journals.cambridge.org/action/di ... id=8259387

It's probably too soon to panic, but I thought that we should all be aware of this, since it does us no good to try to improve our health, if we are unknowingly destroying something as vital as our heart, in the process.

Tex
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Post by Gabes-Apg »

Too Funny

here in oz the margarines here that contain Phytosterols cost double the price

the butter/margarine replacement that i use that is DF/SF/GF is half the cost of normal margarine (so 1/4 cost of the phytosterols) and is far better for you!
Gabes Ryan

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Post by MaggieRedwings »

Thanks for the great research Tex. None here for me either. They sound like something I have a respect for staying away from.

Love, Maggie
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Post by Deb »

Years ago I was in a Mayo study with plant sterols. The first one had the sterol in yogurt and in two weeks my cholesterol dropped 10%. The study was
discontinued as they decided the yogurt wasn't properly packaged (too little product in too large a package). I started a 2nd study which had gel caps of plant sterols taken 3x per day. Again my total cholesterol dropped 10% (from 239 I think to lower 200's). Obviously I wasn't in the placebo group either time. I thought at the time it was a better option than drugs. I did not use them later though as I am not a fan of the margarine and it was the only product it was in which it was available. My cholesterol continues to be in this range (to the chagrin of my MD) but my HDL is 85 and my tryglycerides
are half of what they were. I have also added niacin to my diet just because my MD asked if I would at least do that. I did have a grandmother who lived to nearly 100 who swore that nicotinic acid kept her mind sharp and she was sharp to the end and it can help elevated cholesterol. I think the next time I have my cholesterol checked I'm going to check the size of the particles, as I suspect my level may be slightly elevated due to an overall lower carb/higher fat diet I eat.
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Post by tex »

Deb,

A low carb, higher fat diet should lower your cholesterol and triglyceride levels, not increase them.
Abstract

Multiple food allergies required a group of seven patients with elevated serum cholesterol levels to follow a diet in which most of the calories came from beef fat. Their diets contained no sucrose, milk, or grains. They were given nutritional supplements. This is the only group of people in recent times to follow such a diet. During the study, the patients' triglyceride levels decreased from an average of 113 mg/dl to an average of 74 mg/dl; at the same time, their serum cholesterol levels fell from an average of 263 mg/dl to an average of 189 mg/dl. At the beginning of the study, six of the patients had an average high-density lipoprotein percentage of 21%. At the end of the study, the average had risen to 32%. These findings raise an interesting question: are elevated serum cholesterol levels caused in part not by eating animal fat (an extremely "old food"), but by some factor in grains, sucrose, or milk ("new foods") that interferes with cholesterol metabolism?
http://www.ncbi.nlm.nih.gov/sites/entre ... t=Abstract

Tex
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Post by sarkin »

I am really looking forward to my upcoming cholesterol test. I wish I'd gotten it done just before I got sick, and then I'd have a really recent comparison. My cholesterol had been somewhat elevated, with a great HDL ratio. My triglycerides were fine, but I bet they're lower now. I think I'll print that article for my next doctor chat ;)

Do you suppose this is "more true" for those of us with gluten sensitivity? (Which, as you know, I believe is just about everybody... more or less?)

I wonder whether 'elevated' total cholesterol is an early sign of inflammation, and the LDL/HDL ratio starts going out of whack next, and eventually the homocysteine and CRP numbers show up ringing alarms.

On your original posted article - I have never understood why anyone imagined it would even be possible to make a magic pill out of something that seems to work. If something works, do that thing. It seems to me that the chance of micronizing or extracting or isolating a magic pill from *anything* is vanishingly small. It's like trying to turn all the components of successful parenting into a certain number of minutes of daily hugs, so it can be automated.

Even better, the original idea was to add these magic substances to margarine - which turns out to be worse for most people than butter.

The wrong questions just keep not leading to the right answers, I notice ;)

Love,
Sara
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Post by tex »

Sara wrote:I wonder whether 'elevated' total cholesterol is an early sign of inflammation, and the LDL/HDL ratio starts going out of whack next, and eventually the homocysteine and CRP numbers show up ringing alarms.
:shrug: All I know is that my total cholesterol has always been near the upper end of the "normal" range, my HDL has always been at the lower end of the "normal" range, and my LDL has always been at the upper end of the "normal range". :sigh: So far, my CRP is fine, but it was never checked until several months after the removal of a section of my terminal ileum, and since the terminal ileum is where cholesterol is recycled, my total cholesterol level began to decline, a few months after my surgery. My homocysteine level has never been checked, that I'm aware of.

Cholesterol may not be a marker for inflammation, (or imminent inflammation), because as we age, higher cholesterol levels are connected with longevity, (IOW, a higher cholesterol level appears to be protective of infections and cancer, with increasing age).

http://jama.ama-assn.org/content/272/17/1335.abstract

http://www.ncbi.nlm.nih.gov/pubmed/9343498

http://qjmed.oxfordjournals.org/content ... eytype=ref

http://www.huffingtonpost.com/dr-mark-h ... 90687.html

http://www.ctds.info/low_cholesterol.html

And, based on the data connected with the article at the following link, which discusses the damage done to the heart when cholesterol is replaced by phytosterols - what if it's not the presence of the phytosterols that is so bad? What if lowering the cholesterol level by any means is the source of the damage to the heart that was discovered in the research project? Prior to this, maybe no one ever bothered to check to see if lowering the cholesterol level causes damage to heart cells. :shrug: . . . Just thinking out loud.

http://journals.cambridge.org/action/di ... id=8259387

Love,
Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by sarkin »

Interesting indeed... a friend with pretty severe Crohn's had extremely low cholesterol. I believe that's not uncommon with CD.

I wouldn't be surprised if our cholesterol would fluctuate with age and season and diet, meaning it might sometimes go down 'naturally' (and that might sometimes even be associated with Some Good Outcome). But that wouldn't mean that actions to reduce it are good, and even if there is a useful action with a good outcome, it doesn't mean that ANY step taken to reduce total cholesterol is a good thing. (Of course, it would be a fantastic thing for the reputation of whoever published those results, regardless of true human health consequences... how wrong is that??)

And indeed... what if driving cholesterol down does damage, beyond the damage that's caused by statins? I believe I've been too kind in my heart toward Big Pharma and Unthinking Medicine.

Love,
Sara
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Post by Deb »

Tex, from what I'm reading on low carb forums quite a few of us see a rise in our total cholesterol when going low carb including a rise in HDL but much improvements in our triglycerides, which is what I've seen. When the doctors freak out, many are having their cholesterol particle size tested and most are coming back big and fluffy versus small and dense, which apparently is much less of a risk and correlates with triglyceride levels. Some end up seeing their cholesterol levels going down over time. The OP at this site has a lot of information I've found interesting.
http://forums.somethingawful.com/showth ... id=3407406
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Post by tex »

Hmmmmm. I guess I'm not much of a cholesterol connoisseur. I develop a state of information overload when I start reading there - there's a lot of information there. My eyes start to glaze over before I get very far. LOL.

I have no idea if my cholesterol is big and fluffy, or small and dense. :headscratch: My triglyceride level has always been pretty decent, except for when I was having a TIA. To be honest, I've never been concerned about my cholesterol level, but the drug companies have certainly convinced most doctors to be concerned about it.

Thanks for the link,
Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by TXBrenda »

Since ya'll are talking about cholesterol, I'll post my after labs from the weight management plan I finished the first part of April. My total cholesterol was down 60 pts to 162, triglyceride cut in half to 83, LDL down 46 to 107, HDL only up 1 to 40. Lost 23 pounds overall. Think I need to stick with the process? Just kidding!

Thanks posting this to open our eyes a little further!
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Post by tex »

Brenda,

Wow! Those are great results. Congratulations!

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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