Linda's Enterolab results

[Linda in BC]

Well, here they are. Feel free toput them in the database.

Date: 6/16/2010
Name: Steward, Linda

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value
Fecal Anti-gliadin IgA 13 Units (Normal Range is less than 10 Units)

Fecal Anti-tissue Transglutaminase IgA 6 Units (Normal Range is less than 10 Units)

Quantitative Microscopic Fecal Fat Score 299 Units (Normal Range is less than 300 Units)

Fecal Anti-casein (cow’s milk) IgA 6 Units (Normal Range is less than 10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0202

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 2,3 (Subtype 2,7)

Soy Sensitivity Stool Test
Fecal Anti-soy IgA 6 Units (Normal Range is less than 10 Units)

Interpretation of Fecal Anti-gliadin IgA: Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.

As far as I can see, it says I am gluten sensitive with two not so good genes, but that is all. NOT sensitive to CASEIN , OR SOY! that is just too weird because I am sure I am casein sensitive and after the reaction I had to soy last week, and how much better I was when I quit using soy milk , am pretty sure about soy, too. Maybe I have been Casein free so long ( six years or so) I no longer have the IgA for that in me. I can't be one of the one in 500 that can't make IgA because my level was elevated for gluten. Just don't klnow what to think about the soy.

Interpretation of Fecal Anti-tissue Transglutaminase IgA: The level of intestinal IgA antibodies to the human enzyme tissue transglutaminase was below the upper limit of normal, and hence, there is no evidence of a gluten-induced autoimmune reaction.

Interpretation of Quantitative Microscopic Fecal Fat Score: Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no malabsorbed dietary fat in stool indicating that digestion and absorption of nutrients is currently normal.
Boy, I am right on the edge with this one...

Interpretation of Fecal Anti-casein (cow’s milk) IgA: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 other than by HLA-DQB1*0201, or DQ3 other than by HLA-DQB1*0302). Furthermore, HLA-DQ2 genes other than by HLA-DQB1*0201 can be associated with celiac sprue in rare cases. Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.

Interpretation of Fecal Anti-soy IgA: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.


Not at all what I expected. I suppose I should be doing a happy dance because I am supposedly not sensitive to soy and casein, only gluten, but I can't because I find it hard to believe given my experiences. Have you ever seen anything like this , Tex, where someone has lived for 6 years avoiding something they know bothers them, and it comes up negative?
Linda

[tex]

Linda,

If you didn't ingest any casein within roughly 3 to 4 weeks prior to collecting the sample, then that explains why you tested negative to casein. Casein antibody production decays very rapidly, once it is withdrawn from the diet, (unlike gluten, for which the body continues to produce antibodies for up to two years after it is withdrawn from the diet). Another possibility is that you are only lactose intolerant.

Soy is similar, with a short antibody persistence. If you didn't eat any soy within a few weeks prior to the collection of the sample, then you wouldn't be producing any antibodies, so you couldn't trigger a positive test result. If you were eating soy, and you feel that you are sensitive to it, then the negative test result could mean that you are not sensitive to the primary protein in soy, but you are sensitive to one of the lesser proteins in soy, (the test only responds to antibodies to the main protein in soy).

At least that's the way that I see it. Thanks for posting these results. I'll add them to the list.

Tex

[Gabes-Apg]

linda
glad you got your results. I am jealous that according to this you can tolerate caesin, but based on what you have said, caesin is not really your friend...

hope the ldn journey is still going well, read your note about your travels and brown rice. not good, hope you recover soon.

are you still in june madness zone or has things settled down?

[Linda in BC]

Hi Gabes,
Thanks so much for taking the time to drop a note during ,what is no doubt, a super busy day. I hope you are well.
I know that I am casein intolerant ( and it is not just lactose as I react severely to even products where the lactose is broken down) so it must be as Tex suggested , that I have been free of it for so long I no longer have antibodies. Gee, if I had known that I'd have eaten some casein before the test, just to have the satisfaction of seeing it confirmed on paper, see how high my numbers were, ( and to get my $500.00 worth! )

Tex, thanks for the insight.

The LDN treatment ( plus boswellia) is not going as well as I would like. Despite being very strict with the "no, no, no, no" diet ( as in no casein, no corn, no soy , no gluten ) I am still reacting and have not a had another D. free day like the two I had the weekend of the 4th of June. Not since I had that soy moccachino. I know, I know.. ( I can hear everyone saying that should not have "experiemented" but according to my lab results I am not even supposed to be reactive to it, so at least now I know that I am...)

Linda

[Stanz]

Well, we are double DQB1 sisters, Linda, different alleles.

I'm actually kind of surprised that you didn't have higher Fecal Anti-gliadin IgA and Fecal Anti-tissue Transglutaminase IgA scores, especially since you have not been strictly GF, as I had been for 4 months prior to when I took the test. My scores were 32 and 21 respectively, yours were 13 and 6 and 6 is in the normal range. With your symptoms, I would have expected them both to be much higher, so in your case I take that as a good thing.

[Linda in BC]

My low numbers might be why I didn't ever really suspect gluten as an intolerance... I don't think I have ever really had consistently strong reactions to it.. not like I (thought) I was having to the casein... Maybe my symptoms were/are excaberated by something else that I have yet to identify! I am grateful that I am probably not as sensitive to tool contamination, etc. as others are.
Linda