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Tex you have authorization to post my results but can you also elaborate on my results? Also I have CC not LC....I guess even Doc's can make mistakes. My mother has been diagnosed with celiac for at least 25 years. Below is my Dr's note to me. Brandy
Hi, You have a NOD 2 mutation and celiac genetics suggestive that you have a 30 fold increased risk of developing celiac disease. I think that your lymphocytic colitis is directly related. I would advise you to try a gluten free diet for at least three months NOD2 is a gene that regulates how your intestine process bacteria.
Component ResultsComponent Your Value Standard Range Units
REFERRAL TEST NAME CELIAC GENETICS
REFERRAL LAB CODE Prometheus Lab
RESULT note:
Celiac Risk Genes Detected: DQ2.5 (HLA DQA1*05:DQB1*0201) and other
non-risk alleles.
DQ Genotype: DQ2 heterozygous
Increased Risk: 10x
Relative Risk: High
Gene test results, help with interpretation
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Hi Brandy,
Thanks for bumping your post up again, and bringing it to my attention. Apparently I did miss it the first time around. I apologize for that.
Prometheus uses a different testing and reporting method than the Red Cross test, (which is the test that EnteroLab uses for DNA). You appear to have the most common celiac gene, carried by 25% of American caucasians, (and also carried by between 90 and 95% of the people who have celiac disease). This is the gene that most people refer to as the DQ2 gene.
The DQ2.5 haplotype responds to the alpha2-gliadin peptide, which is the most plentiful type of gliadin peptide found in gluten, implying that you have a maximum opportunity to react to gluten.
The heterozygous comment simply refers to the fact that you don't have two identical genes. Apparently, the other gene is non-celiac, because they didn't even bother to report it, (which is a ripoff, as far as I'm concerned, because even though it isn't a celiac gene, it is almost surely a gene that predisposes to non-celiac gluten-sensitivity and microscopic colitis). They refer to it as a "non-risk" allele, but that's incorrect, (unless it happens to be one of the uncommon DQ4 genes). That most likely simply means that they're either too ignorant, or too prejudiced to accept Dr. Fine's research, that describes the non-celiac gluten-sensitive genes. FYI, Enterolab always reports both values, and does the test for approximately half of what Prometheus charges.
If you wanted to translate your result into the same form reported by EnteroLab, (the Red Cross test), it would appear this way:
HLA-DQB1 Molecular analysis, Allele 1 0201
Serologic equivalent: HLA-DQ 2 (Subtype 2).
Tex
Thanks for bumping your post up again, and bringing it to my attention. Apparently I did miss it the first time around. I apologize for that.
Prometheus uses a different testing and reporting method than the Red Cross test, (which is the test that EnteroLab uses for DNA). You appear to have the most common celiac gene, carried by 25% of American caucasians, (and also carried by between 90 and 95% of the people who have celiac disease). This is the gene that most people refer to as the DQ2 gene.
The DQ2.5 haplotype responds to the alpha2-gliadin peptide, which is the most plentiful type of gliadin peptide found in gluten, implying that you have a maximum opportunity to react to gluten.
The heterozygous comment simply refers to the fact that you don't have two identical genes. Apparently, the other gene is non-celiac, because they didn't even bother to report it, (which is a ripoff, as far as I'm concerned, because even though it isn't a celiac gene, it is almost surely a gene that predisposes to non-celiac gluten-sensitivity and microscopic colitis). They refer to it as a "non-risk" allele, but that's incorrect, (unless it happens to be one of the uncommon DQ4 genes). That most likely simply means that they're either too ignorant, or too prejudiced to accept Dr. Fine's research, that describes the non-celiac gluten-sensitive genes. FYI, Enterolab always reports both values, and does the test for approximately half of what Prometheus charges.
If you wanted to translate your result into the same form reported by EnteroLab, (the Red Cross test), it would appear this way:
HLA-DQB1 Molecular analysis, Allele 1 0201
Serologic equivalent: HLA-DQ 2 (Subtype 2).
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.