Just doing a bit of reading and found this! I have been experiencing a bit of facial flushing and my kidney function dropped 10 points in the last month (I have impaired function from only having one kidney). Hope someone else finds this helpful. I think instead of doing 100 mg three times a day, I will do little half doses more often to try lessen the strain, but get my levels up ever so gradually. It will be interesting to see what my RBC magnesium test shows.
Clinical manifestations of excess magnesium and hypermagnesaemia (abnormally high serum magnesium levels) include:
Neuromuscular
Loss of deep tendon reflexes
Muscle weakness
Decreased uterine tone
Cardiac
Hypotension (low blood pressure)
Flushing
Central Nervous System
Slurred speech
Lethargy
Other
Paralytic ileus (gastrointestinal paralysis)
Nausea
Warnings
As with all medicinal substances, there are some circumstances wherein magnesium should be avoided. Transdermal magnesium supplementation bypasses gut absorption and is processed through the kidneys primarily. Under normal conditions (e.g. with optimal renal function), any excess serum magnesium, as also any magnesium-rich waste matter carried by the blood, is effectively filtered, processed, and reabsorbed by the kidneys or excreted through the urinary tract.
Universal contraindications for magnesium supplementation of any kind include diagnosed Kidney (renal) Failure and other acute forms of uraemia (kidney dysfunction manifesting diagnosable symptoms).
Transdermal magnesium and impaired renal function
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